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This is consistent with studies in experimental models of cancer, which correlate anti-angiogenic treatment with increased local tumor invasiveness and formation of distant metastasis [289,290,291,292]

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Marked decreases in glial cell line-derived neurotrophic factor (GDNF) were also observed in TLR2-deficient and microbiota-depleted mice, whereas supplementation with GDNF or TLR2 agonist restored the ENS function, indicating that both are prerequisites for ensuring the integrity of ENS ( 3.3 Neurotoxic effects Clinical studies (Gomes et al., 2017) indicate that serum lipopolysaccharide (LPS) levels in patients with T2DM are 1.66-fold higher than in healthy individuals